Blood pressure follows the kidney

Blood pressure and the kidney.

Long term effects of kidney donation on blood pressure and kidney function of donors

Introduction: Kidney transplantation from a live donor has many advantages, but the donor should undergo a major surgery and accept potential morbidity and mortality. In this study, we evaluated the long term effects of nephrectomy on renal function and blood pressure of kidney donors. Methods: In this cross-sectional study, we assessed 195 kidney donors. The controls were 100 healthy individu...

The Kidney in Blood Pressure Regulation

Despite extensive animal and clinical experimentation, the mechanisms responsible for the normal regulation of arterial pressure and development of essential or primary hypertension remain unclear. One basic concept was championed by Guyton and other authors [1–4]: the long-term regulation of arterial pressure is intimately linked to the ability of the kidneys to excrete sufficient sodium chlor...

Suppressing kidney angiotensinogen in blood pressure regulation

The classical renin–angiotensin system (RAS) is activated by renin that is secreted from the juxtaglomerular cells of the afferent arteriole, which cleaves angiotensinogen (Agt), synthesized and released by the liver. This leads to the generation of a potent biologically active peptide, angiotensin II (AngII), which contributes to blood pressure regulation and sodium homeostasis. Recent studies...

Kidney and circadian blood pressure rhythm.

Association between nondipper pattern of circadian rhythm of blood pressure (BP) and impaired renal capacity to excrete sodium into urine was confirmed by Bankir et al1 in this issue of Hypertension based on a large number of subjects. Although this association has been observed in small studies,2,3 their study1 is the first to show it in a large-scale setting, and, therefore, is highly welcome...